Quelltext der Seite CCL5

{{Infobox Protein
| Name             = CCL5
| Bild             = PDB 1eqt EBI.jpg
| Bild_legende     = nach {{PDB|1EQT}}
| Andere Namen     = * RANTES
* Chemokine (C-C Motif) Ligand 5
* SIS-Delta
* D17S136E
* TCP228
* Eosinophil Chemotactic Cytokine
* T-Cell Specific Protein P288
* Beta-Chemokine
* EoCP
* Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted
* Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5;
* C-C Motif Chemokine 5
| PDB              = {{PDB2|1B3A}}, {{PDB2|1EQT}}, {{PDB2|1HRJ}}, {{PDB2|1RTN}}, {{PDB2|1RTO}}, {{PDB2|1U4L}}
| Groesse          = 91 Aminosäuren, 9990 Da
| Kofaktor         = 
| Precursor        = 
| Struktur         = 
| Isoformen        = 
| HGNCid           = 10632
| Symbol           = 
| AltSymbols       = 
| GeneCards        = CCL5
| OMIM             = 187011
| UniProt          = P13501
| MGIid            = 
| CID              = 
| CAS              = 
| CASergänzend     = 
| ATC-Code         = 
| DrugBank         = 
| Wirkstoffklasse  = 
| TCDB             = 
| TranspText       = 
| EC-Nummer        = 
| Kategorie        = 
| Peptidase_fam    = 
| Inhibitor_fam    = 
| Reaktionsart     = 
| Substrat         = 
| Produkte         = 
| MoreEC1          = 
| MoreEC2          = 
| MoreEC3          = 
| Homolog_db       = 
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| Taxon            = 
| Taxon_Ausnahme   = 
| Orthologe        = {{Protein Orthologe
| Spezies1         = Mensch
| Spezies2         = Hausmaus
| S1_EntrezGene    = 6352
| S1_Ensembl       = 
| S1_RefseqmRNA    = 
| S1_RefseqProtein = 
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| S1_GenLoc_chr    = 
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| S1_GenLoc_end    = 
| S1_Uniprot       = P13501
| S2_EntrezGene    = 20304
| S2_Ensembl       = 
| S2_RefseqmRNA    = 
| S2_RefseqProtein = 
| S2_GenLoc_db     = 
| S2_GenLoc_chr    = 
| S2_GenLoc_start  = 
| S2_GenLoc_end    = 
| S2_Uniprot       = P30882
}}
}}
'''CCL5''' ({{enS|CC-chemokine ligand 5}}) ist ein [[Zytokin]] aus der Familie der CC-[[Chemokin]]e.

== Eigenschaften ==
CCL5 ist an [[Entzündung]]sprozessen beteiligt. CCL5 wird unter anderem von [[Zytotoxische T-Zelle|zytotoxischen T-Zellen]] gebildet und bindet [[T-Zelle]]n, [[Monozyt]]en und [[Eosinophile]] durch Bindung der [[Rezeptor (Biochemie)|Rezeptoren]] [[CCR3]],<ref name="pmid8642344">{{cite journal | author = Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS | title = Cloning, expression, and characterization of the human eosinophil eotaxin receptor | journal = J. Exp. Med. | volume = 183 | issue = 5 | pages = 2349–54 | date = 1996-05 | pmid = 8642344 | pmc = 2192548 | doi = 10.1084/jem.183.5.2349 | url =  | issn =  }}</ref><ref name="pmid11449371">{{cite journal | author = Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J | title = Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils | journal = Eur. J. Immunol. | volume = 31 | issue = 7 | pages = 2170–8 | date = 2001-07 | pmid = 11449371 | doi = 10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D | url =  | issn =  }}</ref> [[CCR5]]<ref name="pmid11449371" /><ref name="pmid14637022">{{cite journal | author = Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L | title = Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages | journal = Biochim. Biophys. Acta | volume = 1617 | issue = 1–2 | pages = 80–8 | date = 2003-10 | pmid = 14637022 | doi = 10.1016/j.bbamem.2003.09.006 | url =  | issn =  }}</ref><ref name="pmid11116158">{{cite journal|author=Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, [[Alexandra Trkola|Trkola A]], Marchant D, Clapham PR, Wells TN|title=The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity|journal=J. Biol. Chem.|volume=276|issue=14|pages=10620–6|date=April 2001|pmid=11116158|doi=10.1074/jbc.M010867200|url=|issn=}}</ref> und [[CCR1]].<ref name="pmid11449371" /><ref name="pmid11116158" /> CCL5 aktiviert den [[G-Protein-gekoppelter Rezeptor|GPCR]] [[GPR75]].<ref name="pmid17001303">{{cite journal | author = Ignatov A, Robert J, Gregory-Evans C, Schaller HC | title = RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 | journal = Br. J. Pharmacol. | volume = 149 | issue = 5 | pages = 490–7 | date = 2006-11 | pmid = 17001303 | pmc = 2014681 | doi = 10.1038/sj.bjp.0706909 | url =  | issn =  }}</ref>

CCL5 ist an der Abwehr von Infektionen mit [[HIV]]-1 beteiligt,<ref name="pmid8525373">{{cite journal | author = Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P | title = Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells | journal = Science | volume = 270 | issue = 5243 | pages = 1811–5 | date = 1995-12 | pmid = 8525373 | doi = 10.1126/science.270.5243.1811 | url = https://science.sciencemag.org/content/270/5243/1811 | issn =  }}</ref> da es die Bindung von HIV an seinen Korezeptor CCR5 [[Kompetitive Hemmung|kompetitiv]] hemmt.

== Einzelnachweise ==
<references />

[[Kategorie:Zytokin]]
[[Kategorie:Abkürzung]]
[[Kategorie:Codiert auf Chromosom 17 (Mensch)]]