Quelltext der Seite CDC23

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Das [[Protein]] '''Cell division cycle 23 homolog (S. cerevisiae)''', auch '''CDC23''', wird durch das [[Gen]] ''CDC23'' kodiert.<ref name="entrez">{{cite web | title = Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8697| accessdate = }}</ref>

== Funktion ==
Das humane Protein CDC23 ist seinem Homologon Cdc23 in [[S. cerevisiae]] sehr ähnlich. Das Molekül ist essentiell für das Fortlaufen des [[Zellzyklus]] durch den G2-M-[[Checkpoint (Zellbiologie) | Schadenskontrollpunkt]]. Das Protein ist Bestandteil des [[Anaphase-promoting complex]] (APC), der aus 8 Proteinuntereinheiten besteht und in eukaryotischen Zellen hochkonserviert ist. APC katalysiert die Bildung des [[Cyclin B]]-[[Ubiquitin]]konjugates, das die Ubiquitin-gesteuerte [[Proteolyse]] von Cyclin B bewirkt. Das Protein enthält, wie auch drei weitere Bestandteile des APC-Komplexes, das [[Tetratricopeptid Repeat|TPR]]-[[Strukturmotiv]] als Protein-Protein-Interaktions[[Protein|domäne]].<ref name="entrez" />

== Interaktionen ==
Es wurde nachgewiesen, dass CDC23 mit [[CDC27]] interagiert.<ref name=pmid12956947>{{cite journal | author = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = 2003-09 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}</ref><ref name=pmid10922056>{{cite journal | author = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = 2000-08 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}</ref>

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== Literatur ==
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* {{cite journal | author = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4  | date = 1994-01 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | author = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56  | date = 1997-10 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | author = Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW | title = Identification of a cullin homology region in a subunit of the anaphase-promoting complex | journal = Science | volume = 279 | issue = 5354 | pages = 1219–22  | date = 1998-02 | pmid = 9469815 | doi = 10.1126/science.279.5354.1219 }}
* {{cite journal | author = Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW, Le Beau MM | title = Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias | journal = Genomics | volume = 53 | issue = 2 | pages = 184–90  | date = 1998-10 | pmid = 9790767 | doi = 10.1006/geno.1998.5473 }}
* {{cite journal | author = Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM | title = Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 14500–7  | date = 1999-05 | pmid = 10318877 | doi = 10.1074/jbc.274.20.14500 }}
* {{cite journal | author = Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM | title = Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11317–22  | date = 1999-09 | pmid = 10500174 | pmc = 18031 | doi = 10.1073/pnas.96.20.11317 }}
* {{cite journal | author = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8  | date = 2000-08 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}
* {{cite journal | author = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = 2000-09 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{cite journal | author = Walker MG | title = Drug target discovery by gene expression analysis: cell cycle genes | journal = [[Current Cancer Drug Targets]] | volume = 1 | issue = 1 | pages = 73–83 | date = 2001-05 | pmid = 12188893 | doi = 10.2174/1568009013334241 }}
* {{cite journal | author = Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A | title = Alterations of anaphase-promoting complex genes in human colon cancer cells | journal = Oncogene | volume = 22 | issue = 10 | pages = 1486–90  | date = 2003-03 | pmid = 12629511 | doi = 10.1038/sj.onc.1206224 }}
* {{cite journal | author = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = 2003-09 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}
* {{cite journal | author = Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM | title = Mitotic regulation of the human anaphase-promoting complex by phosphorylation | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6598–609 | date = 2003-12 | pmid = 14657031 | pmc = 291822 | doi = 10.1093/emboj/cdg627 }}
* {{cite journal | author = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5  | date = 2004-08 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | author = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | date = 2004-11 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
* {{cite journal | author = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = 2005-10 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | author = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6  | date = 2006-04 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
* {{cite journal | author = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92  | date = 2006-10 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
* {{cite journal | author = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48  | date = 2006-11 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
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== Einzelnachweise ==
<references />

[[Kategorie:Protein]]