Quelltext der Seite CREB-Binding-Protein

{{Infobox Protein
| Name            = 
| Bild            = 
| Bild_legende    = 
| PDB             = s. UniProt<!-- {{PDB2|1YY1}}, {{PDB2|ABCD}} -->
| Groesse         = 2442 Aminosäuren
| Kofaktor        = 
| Precursor       = 
| Struktur        = 
| Isoformen       = 
| HGNCid          = 2348
| Symbol          = CREBBP
| AltSymbols      = 
| OMIM            = 600140
| UniProt         = Q92793
| MGIid           = 
| CAS             = 
| CASergänzend    = 
| ATC-Code        = <!-- {{ATC|X99|XX99}} -->
| DrugBank        = 
| Wirkstoffklasse = 
| TCDB            = 
| TranspText      = 
| EC-Nummer       = 2.3.1.48
| Kategorie       = Acetyltransferase
| Peptidase_fam   = 
| Inhibitor_fam   = 
| Reaktionsart    = Übertragung einer Acetylgruppe
| Substrat        = Histon + Acetyl-CoA
| Produkte        = Acetylhiston + CoA
| Homolog_db      = HOVERGEN
| Homolog_fam     = CREBBP
| Taxon           = [[Euteleostomi]]
| Taxon_Ausnahme  = 
| Orthologe       = 
}}

Das '''C'''REB-'''B'''inding '''P'''rotein (CREB-Bindeprotein), kurz '''CBP''', ist ein Coaktivator der [[Transkription (Biologie)|Transkription]]. 

CBP stellt eine Verbindung zwischen dem [[Transkriptionsfaktor]] [[CREB]] und dem [[Transkriptionsstartpunkt]] her, indem es als [[Histon-Acetyltransferase]] (HAT, {{EC|2.3.1.48}}) die [[Chromatin]]-Struktur verändert, die dadurch aufgelockert wird. CBP zeigt Homologien zum ebenfalls als HAT wirkenden Protein p300. CBP und p300 acetylieren bevorzugt die [[Histon]]e H3 und H4.

CBP ist ein Coaktivator allgemeiner Natur und wechselwirkt z.&nbsp;B. auch mit [[Transkriptionsfaktor]]en.

== Struktur ==
[[Datei:Structure CREBBP de.svg|500px|zentriert]]

== Klinische Bedeutung ==
Mutationen in diesem [[Gen]] sind für das [[Rubinstein-Taybi-Syndrom]] (RTS) verantwortlich.<ref name="pmid7630403">{{cite journal | author = Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ | title = Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP | journal = [[Nature]] | volume = 376 | issue = 6538 | pages = 348–51 | year = 1995 | month = July | pmid = 7630403 | doi = 10.1038/376348a0 | url = | bibcode=1995Natur.376..348P}}</ref>

== Siehe auch ==
* [[Histonmodifikation]]

== Einzelnachweise ==
<references />

== Literatur ==
* Rolf Knippers: ''Molekulare Genetik''. 9. Auflage. Georg Thieme Verlag, 2006, ISBN 3-13-477009-1
*{{cite journal  | author=Goldman PS, Tran VK, Goodman RH |title=The multifunctional role of the co-activator CBP in transcriptional regulation. |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 103–19; discussion 119–20 |year= 1997 |pmid= 9238849 |doi=  }}
*{{cite journal  | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175–81 |year= 2002 |pmid= 11547919 |doi=10.1080/152165401753544241  }}
*{{cite journal  | author=Matt T |title=Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP). |journal=Acta Med. Austriaca |volume=29 |issue= 3 |pages= 77–9 |year= 2002 |pmid= 12168567 |doi=10.1046/j.1563-2571.2002.02010.x  }}
*{{cite journal  | author=Combes R, Balls M, Bansil L, ''et al.'' |title=An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). |journal=Alternatives to laboratory animals : ATLA |volume=30 |issue= 4 |pages= 365–406 |year= 2002 |pmid= 12234245 |doi=  }}
*{{cite journal  | author=Minghetti L, Visentin S, Patrizio M, ''et al.'' |title=Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. |journal=Neurochem. Res. |volume=29 |issue= 5 |pages= 965–78 |year= 2004 |pmid= 15139295 |doi=10.1023/B:NERE.0000021241.90133.89  }}
*{{cite journal  | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal  | author=Greene WC, Chen LF |title=Regulation of NF-kappaB action by reversible acetylation. |journal=Novartis Found. Symp. |volume=259 |issue=  |pages= 208–17; discussion 218–25 |year= 2004 |pmid= 15171256 |doi=10.1002/0470862637.ch15  }}
*{{cite journal  | author=Liou LY, Herrmann CH, Rice AP |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 9 |pages= 1767–75 |year= 2005 |pmid= 15183343 |doi= 10.1016/j.biocel.2004.02.018 }}
*{{cite journal  | author=Pugliese A, Vidotto V, Beltramo T, ''et al.'' |title=A review of HIV-1 Tat protein biological effects. |journal=Cell Biochem. Funct. |volume=23 |issue= 4 |pages= 223–7 |year= 2005 |pmid= 15473004 |doi= 10.1002/cbf.1147 }}
*{{cite journal  | author=Bannwarth S, Gatignol A |title=HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 61–71 |year= 2005 |pmid= 15638724 |doi=10.2174/1570162052772924  }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11  | pmc=554975 }}
*{{cite journal  | author=Gibellini D, Vitone F, Schiavone P, Re MC |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue= 2 |pages= 95–109 |year= 2005 |pmid= 16035254 |doi=  }}
*{{cite journal  | author=Hetzer C, Dormeyer W, Schnölzer M, Ott M |title=Decoding Tat: the biology of HIV Tat posttranslational modifications. |journal=Microbes Infect. |volume=7 |issue= 13 |pages= 1364–9 |year= 2006 |pmid= 16046164 |doi= 10.1016/j.micinf.2005.06.003 }}
*{{cite journal  | author=Peruzzi F |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |issue=  |pages= 708–17 |year= 2006 |pmid= 16146763 |doi=10.2741/1829  }}

{{SORTIERUNG:Creb Binding Protein}}
[[Kategorie:Epigenetik]]
[[Kategorie:Transkriptionsfaktor]]
[[Kategorie:Transferase]]
[[Kategorie:Codiert auf Chromosom 16 (Mensch)]]