English: Zika virus (ZIKV) virion structure and genome organization. (A) Schematic representation of ZIKV virion structure: ZIKV virion surface is decorated with the E and M proteins, anchored in a lipid bilayer with an icosahedral-like symmetry. Under the viral lipid bilayer is the nucleocapsid composed of the vRNA genome associated with the C protein. (B) Genome organization and polyprotein processing: ZIKV genome (approximately 10.8 kb) is translated as a single polyprotein that is cleaved co- and post-translationally by viral (arrows) and host (diamonds) proteases to yield the three structural proteins C, M and E; and seven NS proteins NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5. The 5′ and 3′ untranslated regions (UTR) are indicated as black lines at the end of the viral genome.