Quelltext der Seite Insulysin

{{Infobox Protein
| Name            = 
| Bild            = Protein_IDE_PDB_2g47.png
| Bild_legende    = <!-- nach {{PDB|ABCD}} -->
| PDB             = {{PDB2|2G47}}, {{PDB2|2G48}}, {{PDB2|2G49}}, {{PDB2|2G54}}, {{PDB2|2G56}}, {{PDB2|2JBU}}, {{PDB2|2JG4}}, {{PDB2|2WBY}}, {{PDB2|2WC0}}, {{PDB2|2WK3}}, {{PDB2|2YPU}}, {{PDB2|3CWW}}, {{PDB2|3E4A}}, {{PDB2|3E4Z}}, {{PDB2|3E50}}, {{PDB2|3H44}}, {{PDB2|3HGZ}}, {{PDB2|3N56}}, {{PDB2|3N57}}, {{PDB2|3OFI}}, {{PDB2|3QZ2}}, {{PDB2|4DTT}}, {{PDB2|4DWK}}, {{PDB2|4GS8}}, {{PDB2|4GSC}}, {{PDB2|4GSF}}, {{PDB2|4IFH}}, {{PDB2|4IOF}}, {{PDB2|4LTE}}, {{PDB2|4M1C}}, {{PDB2|4Q5Z}}, {{PDB2|4QIA}}, {{PDB2|4RAL}}
| Groesse         = 1018 Aminosäuren
| Kofaktor        = Zn<sup>2+</sup>
| Precursor       = 
| Struktur        = Dimer; Oligomer
| Isoformen       = 
| HGNCid          = 5381
| Symbol          = IDE
| AltSymbols      = 
| OMIM            = 146680
| UniProt         = P14735
| MGIid           = 96412
| CAS             = 
| CASergänzend    = 
| ATC-Code        = <!-- {{ATC|X99|XX99}} -->
| DrugBank        = 
| Wirkstoffklasse = 
| TCDB            = 
| TranspText      = 
| EC-Nummer       = 3.4.24.56
| Kategorie       = Metalloprotease
| Peptidase_fam   = M16.002
| Inhibitor_fam   = 
| Reaktionsart    = Hochspezifische Hydrolyse
| Substrat        = Insulin
| Produkte        = Abbauprodukte
| Homolog_db      = 
| Homolog_fam     = 
| Taxon           = [[Eukaryoten]], [[Bakterien]]<ref>[http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=P14735 Homologe bei OMA]</ref>
| Taxon_Ausnahme  = 
| Orthologe       = {{ Protein Orthologe
    | Spezies1 = Mensch
    | Spezies2 = Hausmaus
    | S1_EntrezGene = 3416
 | S1_Ensembl = ENSG00000119912
 | S1_RefseqmRNA = NM_001165946
 | S1_RefseqProtein = NP_001159418
 | S1_GenLoc_db = hg38
 | S1_GenLoc_chr = 10
 | S1_GenLoc_start = 92451684
 | S1_GenLoc_end = 92574076
 | S1_Uniprot = P14735
 | S2_EntrezGene = 15925
 | S2_Ensembl = ENSMUSG00000056999
 | S2_RefseqmRNA = NM_031156
 | S2_RefseqProtein = NP_112419
 | S2_GenLoc_db = mm10
 | S2_GenLoc_chr = 19
 | S2_GenLoc_start = 37268743
 | S2_GenLoc_end = 37337852
 | S2_Uniprot = Q8CGB9
  }}
}}
'''Insulysin (IDE)''' (auch: '''Insulin-abbauendes Enzym''', früher: '''Insulinase''') ist ein [[Enzym]], das in [[Bakterien]] und [[Eukaryoten]] vorkommt. IDE ist in der Lage, in [[Wirbeltiere]]n neben dem [[Protein]] [[Insulin]] mehrere andere extrazellulär auftretende Proteine wie [[beta-Amyloid]] und [[Somatostatin]] abzubauen und so unschädlich zu machen. IDE wird beim Menschen in allen Gewebetypen exprimiert.<ref>{{UniProt|P14735}}</ref><ref>{{cite journal |author=Ciaccio C, Tundo GR, Grasso G, ''et al.'' |title=Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity |journal=J. Mol. Biol. |volume=385 |issue=5 |pages=1556–67 |year=2009 |month=February |pmid=19073193 |doi=10.1016/j.jmb.2008.11.025 |url=}}</ref>

Studien an Han-Chinesen, Deutschen und Moskauern deuten auf eine Assoziation von Polymorphismen am ''IDE''-[[Gen]] mit der Ausbildung eines [[metabolisches Syndrom|metabolischen Syndroms]] und [[Diabetes mellitus]] Typ&nbsp;2. Weiterhin sind niedrige Expressionswerte von IDE statistisch mit dem Auftreten der [[Alzheimer-Krankheit]] verbunden. Insulysin ist außerdem eine Eintrittspforte für die Infektion mit dem [[Varizella-Zoster-Virus]].<ref>{{cite journal |author=Lu X, Huang Y, Liu Y, Wu X, Shi X |title=Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders |journal=Metab. Clin. Exp. |volume=58 |issue=10 |pages=1465–9 |year=2009 |month=October |pmid=19592050 |doi=10.1016/j.metabol.2009.04.027 |url=}}</ref><ref>{{cite journal |author=Rudovich N, Pivovarova O, Fisher E, ''et al.'' |title=Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes |journal=[[J Mol Med]] |volume= |issue= |pages= |year=2009 |month=October |pmid=19809796 |doi=10.1007/s00109-009-0540-6 |url=}}</ref><ref>{{cite journal |author=Slominsky PA, Pivovarova OV, Shadrina MI, et al. |title=Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population |journal=Russian Journal of Genetics |volume=45 |issue=1 |pages=113–7 |year=2009 |month=Januar |pmid= |doi=10.1134/S1022795409010165 |url=}}</ref><ref>{{cite journal |author=Ali MA, Li Q, Fischer ER, Cohen JI |title=The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection |journal=Virology |volume=386 |issue=2 |pages=270–9 |year=2009 |month=April |pmid=19233447 |doi=10.1016/j.virol.2009.01.023 |url=}}</ref><ref>{{cite journal |author=Zuo X, Jia J |title=Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease |journal=Brain Res. |volume=1249 |issue= |pages=1–8 |year=2009 |month=January |pmid=18996360 |doi=10.1016/j.brainres.2008.10.034 |url=}}</ref><ref>{{cite journal |author=de Tullio MB, Morelli L, Castaño EM |title=The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective |journal=Prion |volume=2 |issue=2 |pages=51–6 |year=2008 |month=April |pmid=19098445 |pmc=2634517 |doi= |url=}}</ref>

== Einzelnachweise ==
<references />

[[Kategorie:Peptidase]]
[[Kategorie:Codiert auf Chromosom 10 (Mensch)]]